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Synthesis of the 5′-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide

[Image: see text] The synthesis of the 5′-Se-derivatized thymidine and phosphoramidite is reported, and the Se-phosphoramidite was incorporated into DNA. Because of its high nucleophilicity, this 5′-Se-moiety permits convenient post-synthetic modification of oligonucleotides. The proof of principle...

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Bibliografiske detaljer
Main Authors: Zhang, Wen, Huang, Zhen
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241971/
https://ncbi.nlm.nih.gov/pubmed/21434607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200397c
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