Antihypertensive Treatment Differentially Affects Vascular Sphingolipid Biology in Spontaneously Hypertensive Rats

BACKGROUND: We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolated carotid arteries of SHR leads to vas...

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Hauptverfasser: Spijkers, Léon J. A., Janssen, Ben J. A., Nelissen, Jelly, Meens, Merlijn J. P. M. T., Wijesinghe, Dayanjan, Chalfant, Charles E., De Mey, Jo G. R., Alewijnse, Astrid E., Peters, Stephan L. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240660/
https://ncbi.nlm.nih.gov/pubmed/22195025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029222
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