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G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide

BACKGROUND AND PURPOSE: Calcitonin gene-related peptide (CGRP) has been proposed to relax vascular smooth muscle cells (VSMC) via cAMP and can promote dissociation of endothelin-1 (ET-1) from ET(A) receptors. The latter is not mimicked by other stimuli of adenylate cyclases. Therefore, we evaluated...

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Detalhes bibliográficos
Main Authors: Meens, MJPMT, Mattheij, NJA, van Loenen, PB, Spijkers, LJA, Lemkens, P, Nelissen, J, Compeer, MG, Alewijnse, AE, De Mey, JGR
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415655/
https://ncbi.nlm.nih.gov/pubmed/22074193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01774.x
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