Agonist-dependent modulation of arterial endothelin(A) receptor function

BACKGROUND AND PURPOSE: Endothelin-1 (ET-1) causes long-lasting vasoconstrictions. These can be prevented by ET(A) receptor antagonists but are only poorly reversed by these drugs. We tested the hypothesis that endothelin ET(A) receptors are susceptible to allosteric modulation by endogenous agonist...

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Detalhes bibliográficos
Main Authors: Compeer, MG, Meens, MJPMT, Hackeng, TM, Neugebauer, WA, Höltke, C, De Mey, JGR
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402808/
https://ncbi.nlm.nih.gov/pubmed/22324472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01896.x
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