Agonist-dependent modulation of arterial endothelin(A) receptor function

BACKGROUND AND PURPOSE: Endothelin-1 (ET-1) causes long-lasting vasoconstrictions. These can be prevented by ET(A) receptor antagonists but are only poorly reversed by these drugs. We tested the hypothesis that endothelin ET(A) receptors are susceptible to allosteric modulation by endogenous agonist...

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Autors principals: Compeer, MG, Meens, MJPMT, Hackeng, TM, Neugebauer, WA, Höltke, C, De Mey, JGR
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402808/
https://ncbi.nlm.nih.gov/pubmed/22324472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01896.x
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