Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

We describe the design and synthesis of nonpeptidal antagonists of the peptide hormone cholecystokinin. Several of these compounds have high specificity and nanomolar binding affinity and are active after oral administration. To our knowledge, the design of such agents has not previously been accomp...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Evans, B E, Bock, M G, Rittle, K E, DiPardo, R M, Whitter, W L, Veber, D F, Anderson, P S, Freidinger, R M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1986
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323855/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3014519/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4918
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