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Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

We describe the design and synthesis of nonpeptidal antagonists of the peptide hormone cholecystokinin. Several of these compounds have high specificity and nanomolar binding affinity and are active after oral administration. To our knowledge, the design of such agents has not previously been accomp...

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Detalhes bibliográficos
Main Authors: Evans, B E, Bock, M G, Rittle, K E, DiPardo, R M, Whitter, W L, Veber, D F, Anderson, P S, Freidinger, R M
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC323855/
https://ncbi.nlm.nih.gov/pubmed/3014519
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