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Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

We describe here the pharmacological properties of RP 67580 [(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one], a nonpeptide antagonist of substance P (SP). In vitro, the compound was found to inhibit in a competitive manner (Ki = 4.16 +/- 0.59 nM) [3H]SP binding to...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Garret, C, Carruette, A, Fardin, V, Moussaoui, S, Peyronel, J F, Blanchard, J C, Laduron, P M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52897/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719549/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.10208
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