Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

We describe here the pharmacological properties of RP 67580 [(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one], a nonpeptide antagonist of substance P (SP). In vitro, the compound was found to inhibit in a competitive manner (Ki = 4.16 +/- 0.59 nM) [3H]SP binding to...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Garret, C, Carruette, A, Fardin, V, Moussaoui, S, Peyronel, J F, Blanchard, J C, Laduron, P M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.10208
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!