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Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer’s disease
The largest genetic risk for late-onset Alzheimer’s disease (AD) resides at the apolipoprotein E gene (APOE) locus, which has three common alleles (ε2, ε3, ε4) that encode three isoforms (apoE2, apoE3, apoE4). The very strong association of the APOE ε4 allele with AD risk and its role in the accumul...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237894/ https://ncbi.nlm.nih.gov/pubmed/21907569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conb.2011.08.002 |
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