Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor

A major therapeutic target for Parkinson's disease (PD) is providing increased glial-derived neurotrophic factor (GDNF) to dopaminergic neurons. We tested the hypothesis that innate immune activation increases astrocyte GDNF production and that this is regulated by specific eicosanoid receptors...

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Detalhes bibliográficos
Main Authors: Li, Xianwu, Cudaback, Eiron, Breyer, Richard M., Montine, Kathleen S., Keene, C. Dirk, Montine, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382097/
https://ncbi.nlm.nih.gov/pubmed/22499581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-200279
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