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Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E(2) production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia
Several lines of evidence support immune response in brain as a mechanism of injury in Alzheimer disease (AD). Moreover, immune activation is heightened in apolipoprotein E (APOE) ε4 carriers; inhibitors of prostaglandin (PG) synthesis show a partially protective effect on AD risk from APOE ε4; and...
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| 發表在: | FASEB J |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Federation of American Societies for Experimental Biology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4415020/ https://ncbi.nlm.nih.gov/pubmed/25593125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-262683 |
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