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Contact-dependent T cell activation and T cell stopping require talin1
T cell:antigen presenting cell (APC) contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, a LFA-1 regulator, localizes to the immune synapse with unknown roles in T cell activation. Here, we show that talin1-deficient T cells have defects in contact-dependent T cell s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237745/ https://ncbi.nlm.nih.gov/pubmed/22075696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102028 |
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