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The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation
The focal adhesion kinase inhibitor, PF-562,271, is currently in clinical development for cancer, however it is not known how PF-562,271 affects T cell function. Here, we demonstrate inhibitory effects of PF-562,271 on the activation of primary human and mouse T cells. PF-562,271 inhibits T cell rec...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762933/ https://ncbi.nlm.nih.gov/pubmed/23928188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.07.024 |
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