Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

Current therapies for pancreatic ductal adenocarcinoma (PDA) target individual tumor cells. Focal adhesion kinase (FAK) is activated in PDA and levels are inversely associated with survival. We investigated the effects of PF-562,271 (a small molecule inhibitor of FAK/PYK2) on a) in vitro migration,...

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Autori principali: Stokes, Jayme B., Adair, Sara J., Slack-Davis, Jill K., Walters, Dustin M., Tilghman, Robert W., Hershey, E. Dan, Lowrey, Bryce, Thomas, Keena S., Bouton, Amy H., Hwang, Rosa F., Stelow, Edward B., Parsons, J. Thomas, Bauer, Todd W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213273/
https://ncbi.nlm.nih.gov/pubmed/21903606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0261
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