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Talin-dependent integrin activation is required for fibrin clot retraction by platelets
Talin functions both as a regulator of integrin affinity and as an important mechanical link between integrins and the cytoskeleton. Using genetic deletion of talin, we show for the first time that the capacity of talin to activate integrins is required for fibrin clot retraction by platelets. To fu...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056596/ https://ncbi.nlm.nih.gov/pubmed/20971947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305433 |
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