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Talin-dependent integrin activation is required for fibrin clot retraction by platelets
Talin functions both as a regulator of integrin affinity and as an important mechanical link between integrins and the cytoskeleton. Using genetic deletion of talin, we show for the first time that the capacity of talin to activate integrins is required for fibrin clot retraction by platelets. To fu...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056596/ https://ncbi.nlm.nih.gov/pubmed/20971947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305433 |
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