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Contact-dependent T cell activation and T cell stopping require talin1

T cell:antigen presenting cell (APC) contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, a LFA-1 regulator, localizes to the immune synapse with unknown roles in T cell activation. Here, we show that talin1-deficient T cells have defects in contact-dependent T cell s...

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Detalhes bibliográficos
Main Authors: Wernimont, Sarah A, Wiemer, Andrew J, Bennin, David A, Monkley, Susan J, Ludwig, Thomas, Critchley, David R, Huttenlocher, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237745/
https://ncbi.nlm.nih.gov/pubmed/22075696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102028
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