Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction

Understanding platelet biology has been aided by studies of mice with mutations in key megakaryocytic transcription factors. We have shown that point mutations in the GATA1 cofactor FOG1 that disrupt binding to the nucleosome remodeling and deacetylase (NuRD) complex have erythroid and megakaryocyte...

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Autori principali: Wang, Yuhuan, Meng, Ronghua, Hayes, Vincent, Fuentes, Rudy, Yu, Xiang, Abrams, Charles S., Heijnen, Harry F. G., Blobel, Gerd A., Marks, Michael S., Poncz, Mortimer
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234671/
https://ncbi.nlm.nih.gov/pubmed/21989988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-363580
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