Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction

Understanding platelet biology has been aided by studies of mice with mutations in key megakaryocytic transcription factors. We have shown that point mutations in the GATA1 cofactor FOG1 that disrupt binding to the nucleosome remodeling and deacetylase (NuRD) complex have erythroid and megakaryocyte...

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Autors principals: Wang, Yuhuan, Meng, Ronghua, Hayes, Vincent, Fuentes, Rudy, Yu, Xiang, Abrams, Charles S., Heijnen, Harry F. G., Blobel, Gerd A., Marks, Michael S., Poncz, Mortimer
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234671/
https://ncbi.nlm.nih.gov/pubmed/21989988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-363580
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