Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2 antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two distinguishable forms of this CAR were expressed in EBV-specific cytotoxic T lymphocytes (EBV-CTLs) and activated T cells (ATC...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Louis, Chrystal U., Savoldo, Barbara, Dotti, Gianpietro, Pule, Martin, Yvon, Eric, Myers, G. Doug, Rossig, Claudia, Russell, Heidi V., Diouf, Oumar, Liu, Enli, Liu, Hao, Wu, Meng-Fen, Gee, Adrian P., Mei, Zhuyong, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2011
Pynciau:
Gene Therapy
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234664/
https://ncbi.nlm.nih.gov/pubmed/21984804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-354449
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