CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...

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Main Authors: Savoldo, Barbara, Ramos, Carlos Almeida, Liu, Enli, Mims, Martha P., Keating, Michael J., Carrum, George, Kamble, Rammurti T., Bollard, Catherine M., Gee, Adrian P., Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2011
主題:
Brief Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/
https://ncbi.nlm.nih.gov/pubmed/21540550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110
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