CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Savoldo, Barbara, Ramos, Carlos Almeida, Liu, Enli, Mims, Martha P., Keating, Michael J., Carrum, George, Kamble, Rammurti T., Bollard, Catherine M., Gee, Adrian P., Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2011
Gaiak:
Brief Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/
https://ncbi.nlm.nih.gov/pubmed/21540550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110
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