CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...

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Detalhes bibliográficos
Main Authors: Savoldo, Barbara, Ramos, Carlos Almeida, Liu, Enli, Mims, Martha P., Keating, Michael J., Carrum, George, Kamble, Rammurti T., Bollard, Catherine M., Gee, Adrian P., Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/
https://ncbi.nlm.nih.gov/pubmed/21540550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110
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