CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...

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Bibliografski detalji
Glavni autori: Savoldo, Barbara, Ramos, Carlos Almeida, Liu, Enli, Mims, Martha P., Keating, Michael J., Carrum, George, Kamble, Rammurti T., Bollard, Catherine M., Gee, Adrian P., Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Brief Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/
https://ncbi.nlm.nih.gov/pubmed/21540550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110
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