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CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/ https://ncbi.nlm.nih.gov/pubmed/21540550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110 |
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