CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes,...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Savoldo, Barbara, Ramos, Carlos Almeida, Liu, Enli, Mims, Martha P., Keating, Michael J., Carrum, George, Kamble, Rammurti T., Bollard, Catherine M., Gee, Adrian P., Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2011
Θέματα:
Brief Report
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083795/
https://ncbi.nlm.nih.gov/pubmed/21540550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46110
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