Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2 antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two distinguishable forms of this CAR were expressed in EBV-specific cytotoxic T lymphocytes (EBV-CTLs) and activated T cells (ATC...

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Detalhes bibliográficos
Principais autores: Louis, Chrystal U., Savoldo, Barbara, Dotti, Gianpietro, Pule, Martin, Yvon, Eric, Myers, G. Doug, Rossig, Claudia, Russell, Heidi V., Diouf, Oumar, Liu, Enli, Liu, Hao, Wu, Meng-Fen, Gee, Adrian P., Mei, Zhuyong, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234664/
https://ncbi.nlm.nih.gov/pubmed/21984804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-354449
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