T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

For the adoptive transfer of tumor-directed T lymphocytes to prove effective, there will probably need to be a match between the chemokines the tumor produces and the chemokine receptors the effector T cells express. The Reed-Stemberg cells of Hodgkin lymphoma (HL) predominantly produce thymus- and...

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Main Authors: Di Stasi, Antonio, De Angelis, Biagio, Rooney, Cliona M., Zhang, Lan, Mahendravada, Aruna, Foster, Aaron E., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro, Savoldo, Barbara
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710932/
https://ncbi.nlm.nih.gov/pubmed/19377047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-209650
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