Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of B-cell malignancies. Because the in vivo survival, expansion and anti-lymphoma activity of CAR.19(+) T cells remain suboptimal even when the CAR contains a CD28 costimula...

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Main Authors: Hoyos, Valentina, Savoldo, Barbara, Quintarelli, Concetta, Mahendravada, Aruna, Zhang, Ming, Vera, Juan, Heslop, Helen E, Rooney, Cliona M., Brenner, Malcolm K, Dotti, Gianpietro
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888148/
https://ncbi.nlm.nih.gov/pubmed/20428207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.75
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