CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-generation chimeric antigen receptor (CAR) was safe, but the cells had poor expansion and long-term persistence. We developed a third-generation GD2-CAR (GD2-CAR3) and hypothesized that GD2-CAR3 T cells (CARTs)...

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Dades bibliogràfiques
Publicat a:Mol Ther
Autors principals: Heczey, Andras, Louis, Chrystal U., Savoldo, Barbara, Dakhova, Olga, Durett, April, Grilley, Bambi, Liu, Hao, Wu, Mengfeng F., Mei, Zhuyong, Gee, Adrian, Mehta, Birju, Zhang, Huimin, Mahmood, Nadia, Tashiro, Haruko, Heslop, Helen E., Dotti, Gianpietro, Rooney, Cliona M., Brenner, Malcolm K.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2017
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589058/
https://ncbi.nlm.nih.gov/pubmed/28602436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.012
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