CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-generation chimeric antigen receptor (CAR) was safe, but the cells had poor expansion and long-term persistence. We developed a third-generation GD2-CAR (GD2-CAR3) and hypothesized that GD2-CAR3 T cells (CARTs)...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Heczey, Andras, Louis, Chrystal U., Savoldo, Barbara, Dakhova, Olga, Durett, April, Grilley, Bambi, Liu, Hao, Wu, Mengfeng F., Mei, Zhuyong, Gee, Adrian, Mehta, Birju, Zhang, Huimin, Mahmood, Nadia, Tashiro, Haruko, Heslop, Helen E., Dotti, Gianpietro, Rooney, Cliona M., Brenner, Malcolm K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Gene & Cell Therapy 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589058/
https://ncbi.nlm.nih.gov/pubmed/28602436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.012
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