CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-generation chimeric antigen receptor (CAR) was safe, but the cells had poor expansion and long-term persistence. We developed a third-generation GD2-CAR (GD2-CAR3) and hypothesized that GD2-CAR3 T cells (CARTs)...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Ther
मुख्य लेखकों: Heczey, Andras, Louis, Chrystal U., Savoldo, Barbara, Dakhova, Olga, Durett, April, Grilley, Bambi, Liu, Hao, Wu, Mengfeng F., Mei, Zhuyong, Gee, Adrian, Mehta, Birju, Zhang, Huimin, Mahmood, Nadia, Tashiro, Haruko, Heslop, Helen E., Dotti, Gianpietro, Rooney, Cliona M., Brenner, Malcolm K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Gene & Cell Therapy 2017
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589058/
https://ncbi.nlm.nih.gov/pubmed/28602436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.012
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