Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells

PURPOSE: The multiple mechanisms used by solid tumors to suppress tumor-specific immune responses are a major barrier to the success of adoptively-transferred tumor-specific T-cells. Since viruses induce potent innate and adaptive immune responses, we hypothesized that the immunogenicity of viruses...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Tanaka, Miyuki, Tashiro, Haruko, Omer, Bilal, Lapteva, Natasha, Ando, Jun, Ngo, Minhtran, Mehta, Birju, Dotti, Gianpietro, Kinchington, Paul R., Leen, Ann M., Rossig, Claudia, Rooney, Cliona M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511585/
https://ncbi.nlm.nih.gov/pubmed/28183713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2138
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