Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence. The use of virus-specific T cells (VSTs) as carriers for CARs may overcome this limitation since CAR-VSTs can be boosted by viral vaccines or o...

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Detalles Bibliográficos
Publicado en:Front Med (Lausanne)
Main Authors: Omer, Bilal, Castillo, Paul A., Tashiro, Haruko, Shum, Thomas, Huynh, Mai T. A., Cardenas, Mara, Tanaka, Miyuki, Lewis, Andrew, Sauer, Tim, Parihar, Robin, Lapteva, Natalia, Schmueck-Henneresse, Michael, Mukherjee, Malini, Gottschalk, Stephen, Rooney, Cliona M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297364/
https://ncbi.nlm.nih.gov/pubmed/30619856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2018.00343
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