Constitutive signaling from an engineered IL-7 receptor promotes durable tumor elimination by tumor redirected T-cells

Successful adoptive T-cell immunotherapy of solid tumors will require improved expansion and cytotoxicity of tumor-directed T cells within tumors. Providing recombinant or transgenic cytokines may produce the desired benefits but are associated with significant toxicities, constraining clinical use....

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Shum, Thomas, Omer, Bilal, Tashiro, Haruko, Kruse, Robert L., Wagner, Dimitrios L., Parikh, Kathan, Yi, Zhongzhen, Sauer, Tim, Liu, Daofeng, Parihar, Robin, Castillo, Paul, Liu, Hao, Brenner, Malcolm K., Metelitsa, Leonid S., Gottschalk, Stephen, Rooney, Cliona M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669830/
https://ncbi.nlm.nih.gov/pubmed/28830878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0538
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