HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice

BACKGROUND AIMS: Chronic hepatitis B virus (HBV) infection remains incurable. While HBsAg-specific chimeric antigen receptor (HBsAg-CAR) T-cells have been generated, they have not been tested in animal models with authentic HBV infection. METHODS: We generated a novel CAR targeting HBsAg, and evalua...

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Bibliographic Details
Published in:Cytotherapy
Main Authors: Kruse, Robert L., Shum, Thomas, Tashiro, Haruko, Barzi, Mercedes, Yi, Zhongzhen, Whitten-Bauer, Christina, Legras, Xavier, Bissig-Choisat, Beatrice, Garaigorta, Urtzi, Gottschalk, Stephen, Bissig, Karl-Dimiter
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038120/
https://ncbi.nlm.nih.gov/pubmed/29631939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2018.02.002
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