Comprehensive approach for identifying the T-cell subset origin of CD3 and CD28 antibody-activated chimeric antigen receptor-modified T-cells

The outcome of therapy with CAR-modified T-ells is strongly influenced by the subset origin of the infused T-cells. However, since polyclonally activated T-cells acquire a largely CD45RO(+)CCR7(−) effector memory phenotype after expansion, regardless of subset origin, it is impossible to know which...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Schmueck-Henneresse, Michael, Omer, Bilal, Shum, Thomas, Tashiro, Haruko, Mamonkin, Maksim, Lapteva, Natalia, Sharma, Sandhya, Rollins, Lisa, Dotti, Gianpietro, Reinke, Petra, Volk, Hans-Dieter, Rooney, Cliona M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536854/
https://ncbi.nlm.nih.gov/pubmed/28550199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601494
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