In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin’s Lymphomas

Second-generation (2G) chimeric antigen receptors (CARs) targeting CD19 are highly active against B cell malignancies, but it is unknown whether any of the costimulatory domains incorporated in the CAR have superior activity to others. Because CD28 and 4-1BB signaling activate different pathways, co...

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書誌詳細
出版年:Mol Ther
主要な著者: Ramos, Carlos A., Rouce, Rayne, Robertson, Catherine S., Reyna, Amy, Narala, Neeharika, Vyas, Gayatri, Mehta, Birju, Zhang, Huimin, Dakhova, Olga, Carrum, George, Kamble, Rammurti T., Gee, Adrian P., Mei, Zhuyong, Wu, Meng-Fen, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Savoldo, Barbara, Dotti, Gianpietro
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Gene & Cell Therapy 2018
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277484/
https://ncbi.nlm.nih.gov/pubmed/30309819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.09.009
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