In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin’s Lymphomas

Second-generation (2G) chimeric antigen receptors (CARs) targeting CD19 are highly active against B cell malignancies, but it is unknown whether any of the costimulatory domains incorporated in the CAR have superior activity to others. Because CD28 and 4-1BB signaling activate different pathways, co...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Ramos, Carlos A., Rouce, Rayne, Robertson, Catherine S., Reyna, Amy, Narala, Neeharika, Vyas, Gayatri, Mehta, Birju, Zhang, Huimin, Dakhova, Olga, Carrum, George, Kamble, Rammurti T., Gee, Adrian P., Mei, Zhuyong, Wu, Meng-Fen, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Savoldo, Barbara, Dotti, Gianpietro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277484/
https://ncbi.nlm.nih.gov/pubmed/30309819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.09.009
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