In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin’s Lymphomas

Second-generation (2G) chimeric antigen receptors (CARs) targeting CD19 are highly active against B cell malignancies, but it is unknown whether any of the costimulatory domains incorporated in the CAR have superior activity to others. Because CD28 and 4-1BB signaling activate different pathways, co...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Ther
मुख्य लेखकों: Ramos, Carlos A., Rouce, Rayne, Robertson, Catherine S., Reyna, Amy, Narala, Neeharika, Vyas, Gayatri, Mehta, Birju, Zhang, Huimin, Dakhova, Olga, Carrum, George, Kamble, Rammurti T., Gee, Adrian P., Mei, Zhuyong, Wu, Meng-Fen, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Savoldo, Barbara, Dotti, Gianpietro
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Gene & Cell Therapy 2018
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277484/
https://ncbi.nlm.nih.gov/pubmed/30309819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.09.009
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