Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

Cytotoxic T lymphocytes (CTLs) directed to nonviral tumor–associated antigens do not survive long term and have limited antitumor activity in vivo, in part because such tumor cells typically lack the appropriate costimulatory molecules. We therefore engineered Epstein-Barr virus (EBV)-specific CTLs...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pule, Martin A, Savoldo, Barbara, Myers, G Doug, Rossig, Claudia, Russell, Heidi V, Dotti, Gianpietro, Huls, M Helen, Liu, Enli, Gee, Adrian P, Mei, Zhuyong, Yvon, Eric, Weiss, Heidi L, Liu, Hao, Rooney, Cliona M, Heslop, Helen E, Brenner, Malcolm K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749734/
https://ncbi.nlm.nih.gov/pubmed/18978797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1882
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