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An Inducible Caspase 9 Suicide Gene to Improve the Safety of Mesenchymal Stromal Cell Therapies

Mesenchymal stromal cells (MSCs) have been infused in hundreds of patients to date, with minimal reported side effects. However, follow-up is limited and long term side effects are unknown. Because several animal models have raised safety concerns, we sought to develop a system allowing control over...

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Hlavní autoři: Ramos, Carlos A., Asgari, Zahra, Liu, Enli, Yvon, Eric, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Dotti, Gianpietro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290395/
https://ncbi.nlm.nih.gov/pubmed/20506146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.433
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