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Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage
MDM2 is a major regulator of p53 by acting as a ubiquitin E3 ligase. The central acidic domain and C-terminal RING domain of MDM2 are both indispensable for ubiquitination of p53. Our previous study suggested that ATM phosphorylation of MDM2 near the C terminus inhibits RING domain oligomerization,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233024/ https://ncbi.nlm.nih.gov/pubmed/21986495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05553-11 |
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