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Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction
The RING domain ubiquitin E3 ligase MDM2 is a key regulator of p53 degradation and a mediator of signals that stabilize p53. The current understanding of the mechanisms by which MDM2 posttranslational modifications and protein binding cause p53 stabilization remains incomplete. Here we present evide...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135571/ https://ncbi.nlm.nih.gov/pubmed/24842904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00246-14 |
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