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Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Missense p53 mutants often accumulate in tumors and drive progression through gain of function. MDM2 efficiently degrades wild-type p53 but fails to degrade mutant p53 in tumor cells. Previous studies revealed that mutant p53 inhibits MDM2 autoubiquitination, suggesting that the interaction inhibits...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell Biol |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6362316/ https://ncbi.nlm.nih.gov/pubmed/30455251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00375-18 |
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