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Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain
MDM2 regulates p53 predominantly by promoting p53 ubiquitination. However, ubiquitination-independent mechanisms of MDM2 have also been implicated. Here we show that MDM2 inhibits p53 DNA binding activity in vitro and in vivo. MDM2 binding promotes p53 to adopt a mutant-like conformation, losing rea...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091211/ https://ncbi.nlm.nih.gov/pubmed/21454483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228981 |
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