Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

MDM2 regulates p53 predominantly by promoting p53 ubiquitination. However, ubiquitination-independent mechanisms of MDM2 have also been implicated. Here we show that MDM2 inhibits p53 DNA binding activity in vitro and in vivo. MDM2 binding promotes p53 to adopt a mutant-like conformation, losing rea...

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Bibliografische gegevens
Hoofdauteurs: Cross, Brittany, Chen, Lihong, Cheng, Qian, Li, Baozong, Yuan, Zhi-Min, Chen, Jiandong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091211/
https://ncbi.nlm.nih.gov/pubmed/21454483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228981
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