A carregar...
Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage
MDM2 is a major regulator of p53 by acting as a ubiquitin E3 ligase. The central acidic domain and C-terminal RING domain of MDM2 are both indispensable for ubiquitination of p53. Our previous study suggested that ATM phosphorylation of MDM2 near the C terminus inhibits RING domain oligomerization,...
Na minha lista:
| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233024/ https://ncbi.nlm.nih.gov/pubmed/21986495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05553-11 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|