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The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation
It is widely accepted that DNA damage induces rapid degradation of MDM2 through phosphorylation, resulting in a transient reduction of MDM2 level. Elimination of MDM2 is a logical mechanism that stabilizes p53. This phenomenon has been reproduced by many independent studies and is frequently referen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100889/ https://ncbi.nlm.nih.gov/pubmed/21386656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.7.15249 |
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