Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
p53 activation prevents the proliferation of genetically unstable cells. Conversely, p53 antagonism by its transcriptional target, the E3 ubiquitin ligase MDM2, is critical for the viability of unstressed, cycling cells. We demonstrate that MDM2 induces the degradation of p53 in both the nucleus and...
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| Publicado no: | EMBO J |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15029243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600145 |
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