DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53

Mouse embryo fibroblasts (MEFs) expressing the adenovirus E1A protein undergo apoptosis upon exposure to ionizing radiation. We show here that immediately following γ-irradiation, latent p53 formed a complex with the catalytic subunit of the DNA-dependent protein kinase (DNA-PK(CS)). The complex for...

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Pubblicato in:	EMBO J
Autori principali:	Woo, Richard A., Jack, Melissa T., Xu, Yang, Burma, Sandeep, Chen, David J., Lee, Patrick W.K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065413/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf307
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