DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53

Mouse embryo fibroblasts (MEFs) expressing the adenovirus E1A protein undergo apoptosis upon exposure to ionizing radiation. We show here that immediately following γ-irradiation, latent p53 formed a complex with the catalytic subunit of the DNA-dependent protein kinase (DNA-PK(CS)). The complex for...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Woo, Richard A., Jack, Melissa T., Xu, Yang, Burma, Sandeep, Chen, David J., Lee, Patrick W.K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065413/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf307
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