DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53

Mouse embryo fibroblasts (MEFs) expressing the adenovirus E1A protein undergo apoptosis upon exposure to ionizing radiation. We show here that immediately following γ-irradiation, latent p53 formed a complex with the catalytic subunit of the DNA-dependent protein kinase (DNA-PK(CS)). The complex for...

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Bibliografske podrobnosti

izdano v:	EMBO J
Principais autores:	Woo, Richard A., Jack, Melissa T., Xu, Yang, Burma, Sandeep, Chen, David J., Lee, Patrick W.K.
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2002
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065413/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf307
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