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DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53
Mouse embryo fibroblasts (MEFs) expressing the adenovirus E1A protein undergo apoptosis upon exposure to ionizing radiation. We show here that immediately following γ-irradiation, latent p53 formed a complex with the catalytic subunit of the DNA-dependent protein kinase (DNA-PK(CS)). The complex for...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126062/ https://ncbi.nlm.nih.gov/pubmed/12065413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf307 |
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