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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
Rapid activation of p53 by ionizing irradiation is a classic DNA damage response mediated by the ATM kinase. However, the major signalling target and mechanism that lead to p53 stabilization are unknown. We show in this report that ATM induces p53 accumulation by phosphorylating the ubiquitin E3 lig...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797053/ https://ncbi.nlm.nih.gov/pubmed/19816404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.294 |
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