Differential Metabolism of Organic Nitrates by Aldehyde Dehydrogenase 1a1 and 2: Substrate Selectivity, Enzyme Inactivation, and Active Cysteine Sites

Organic nitrate vasodilators (ORN) exert their pharmacologic effects through the metabolic release of nitric oxide (NO). Mitochondrial aldehyde dehydrogenase (ALDH2) is the principal enzyme responsible for NO liberation from nitroglycerin (NTG), but lacks activity towards other ORN. Cytosolic aldehy...

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Autors principals: Tsou, Pei-Suen, Page, Nathaniel A., Lee, Sean G., Fung, Sun Mi, Keung, Wing Ming, Fung, Ho-Leung
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231853/
https://ncbi.nlm.nih.gov/pubmed/21818694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9295-4
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