Differential Metabolism of Organic Nitrates by Aldehyde Dehydrogenase 1a1 and 2: Substrate Selectivity, Enzyme Inactivation, and Active Cysteine Sites

Organic nitrate vasodilators (ORN) exert their pharmacologic effects through the metabolic release of nitric oxide (NO). Mitochondrial aldehyde dehydrogenase (ALDH2) is the principal enzyme responsible for NO liberation from nitroglycerin (NTG), but lacks activity towards other ORN. Cytosolic aldehy...

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Main Authors: Tsou, Pei-Suen, Page, Nathaniel A., Lee, Sean G., Fung, Sun Mi, Keung, Wing Ming, Fung, Ho-Leung
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231853/
https://ncbi.nlm.nih.gov/pubmed/21818694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9295-4
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