Differential Metabolism of Organic Nitrates by Aldehyde Dehydrogenase 1a1 and 2: Substrate Selectivity, Enzyme Inactivation, and Active Cysteine Sites

Organic nitrate vasodilators (ORN) exert their pharmacologic effects through the metabolic release of nitric oxide (NO). Mitochondrial aldehyde dehydrogenase (ALDH2) is the principal enzyme responsible for NO liberation from nitroglycerin (NTG), but lacks activity towards other ORN. Cytosolic aldehy...

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Autori principali: Tsou, Pei-Suen, Page, Nathaniel A., Lee, Sean G., Fung, Sun Mi, Keung, Wing Ming, Fung, Ho-Leung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231853/
https://ncbi.nlm.nih.gov/pubmed/21818694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9295-4
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