Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarate (2-HG), respectively. Here we demonstrate that 2-HG is a competitive inhibitor of multiple α-KG-depen...

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Detalhes bibliográficos
Main Authors: Xu, Wei, Yang, Hui, Liu, Ying, Yang, Ying, Wang, Ping, Kim, Se-Hee, Ito, Shinsuke, Yang, Chen, Wang, Pu, Xiao, Meng-Tao, Liu, Li-xia, Jiang, Wen-qing, Liu, Jing, Zhang, Jin-ye, Wang, Bin, Frye, Stephen, Zhang, Yi, Xu, Yan-hui, Lei, Qun-ying, Guan, Kun-Liang, Zhao, Shi-min, Xiong, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229304/
https://ncbi.nlm.nih.gov/pubmed/21251613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.12.014
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